中长期暴露于空气温度和表观遗传年龄加速之间的关联
Wenli Ni1, Nikolaos Nikolaou1, Cavin K Ward-Caviness2
1Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, Neuherberg, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, Pettenkofer School of Public Health, LMU Munich, Munich, Germany.
Environment international
|July 30, 2023
概括
高温加速表观遗传衰老,这是衰老的生物指标. 这项研究将长时间的热暴露与表观遗传衰老加速的增加联系在一起,突出了与气候变化相关的新健康风险.
科学领域:
- 环境健康 环境健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是指老年学的学科.
背景情况:
- 气候变化和人口老龄化带来了越来越多的全球健康挑战.
- 表观遗传加速衰老是一种生物衰老的生物标志物.
- 空气温度对表观遗传衰老的影响仍然未被探索.
研究的目的:
- 调查中长期空气温度暴露与表观遗传衰老加速之间的关联.
- 量化不同温度暴露时间对多个表观遗传时钟的影响.
主要方法:
- 利用来自德国奥格斯堡1,725名 (KORA F4) 和1,877名 (FF4) 参与者的数据.
- 使用分布式滞后非线性模型的概括估计方程 (GEE) 来分析温度效应.
- 使用五种不同的表观遗传时钟 (HorvathAA,HannumAA,PhenoAA,GrimAA,SkinBloodAA) 评估表观遗传年龄加速.
主要成果:
- 高温暴露 (8周和4周的移动平均值) 与多个时钟的表观遗传年龄加速增加显著相关.
- 每年平均气温上升1°C与所有五种指标中的表观遗传衰老加速相关.
- 对于不同的温度暴露场景,量化了表观遗传年龄加速年数的具体增加.
结论:
- 这项研究提供了第一个证据,将中长期暴露于高空气温度与增加的表观遗传衰老加速联系起来.
- 空气温度升高是影响生物衰老的新型环境风险因素.
- 这些发现强调了气候变化对老龄化过程的健康影响.
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