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新型α-ketoamide衍生物的发现和结构-活性关系研究针对SARS-CoV-2主要蛋白酶

Chong Huang1, Rui Zeng1, Jingxin Qiao1

  • 1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.

European journal of medicinal chemistry
|July 30, 2023
PubMed
概括

研究人员发现了新型的α-ketoamide衍生物,可以抑制SARS-CoV-2主要蛋白酶 (Mpro),这是COVID-19治疗的关键目标. 化合物27h表现出强大的抗病毒活性和有利的特性,使其成为药物开发的有希望的头.

关键词:
这是一种M(pro) 抑制剂.这就是SARS-CoV-2病毒.结构与活动的关系.α-基托胺胺衍生物的产生.

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