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通过UPLC-MS在甘中发现并量化具有抑制 ангиотензин转化酶活性的化合物

Haoran Li¹, Yicheng Zhang¹, Gaole Dai¹

¹Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

|July 30, 2023

概括

甘含有抑制血管素转化酶 (ACE) 的化合物,这是心血管疾病治疗的关键标. 利科哈尔科尼B显示出最强大的ACE抑制活性,突出了甘.

科学领域:

药理学和自然产品化学化学
心血管疾病研究研究

背景情况:

甘草是一种传统的草药,用于治疗心血管疾病.
ангиотензин转化酶 (ACE) 是心血管治疗的关键标.
有限的研究存在于甘草的ACE抑制潜力.

研究的目的:

为了识别和描述甘中ACE抑制化合物.
用一种新的光探针来评估甘成分的ACE抑制活性.
开发一种方法来量化甘中的活性化合物.

主要方法:

使用聚合诱导排放 (AIE) 光探针进行活动引导分成.
超高性能液态色谱-四极飞行时间质谱 (UPLC-QTOF-MS) 用于化合物识别.
建立一个UPLC-Q-MS方法来量化活性化合物.

主要成果:

九个甘成分表现出抑制ACE的活性.
确定了46种化合物,其中7种已被证实是活性化合物.
利科哈尔康B显示出最高的ACE抑制活性 (IC50 = 0.24μM).

结论:

甘草是天然ACE抑制剂的有希望的来源.
利科哈尔康B是一种强大的ACE抑制剂.
这些发现支持开发用于心血管健康的甘制品.

关键词:

活性成分有效成分聚合诱导的排放量聚合诱导的排放量 ангиотензин转化酶抑制剂抑制剂甘露是一种甘.量化量化量化量化在 UPLC-QTOF-MS 中.

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