内膜:抑郁症内皮功能障碍的一个新生物标志物?
Ebru Şahan1, Eray Metin Güler2, Aise Tangılntız1
1Department of Psychiatry, Bezmialem Vakif University, Istanbul, Turkey.
Journal of psychiatric research
|July 30, 2023
概括
与健康个体相比,双极性抑郁症和严重抑郁症患者的血清内分泌水平显著升高,这表明潜在的内皮损伤. 双极性抑郁症中的更高的内分泌水平可能表明更大的内皮功能障碍.
科学领域:
- 生物化学 生物化学
- 心血管医学 心血管医学
- 精神病学是一个精神病学.
背景情况:
- 抑郁症与炎症和氧化应激增加有关,导致内皮功能障碍.
- 内皮功能障碍有助于抑郁障碍中的心血管并发症.
- 在内皮损伤时分泌的蛋白质甘氨酸Endocan,可以作为内皮损伤的生物标志物.
研究的目的:
- 为了研究双相抑郁症和重度抑郁症患者的血清内分泌水平.
- 评估内分泌水平与抑郁症中的内皮损伤之间的关联.
- 为了比较抑郁患者和健康对照者之间的内分泌水平.
主要方法:
- 在31名患有双极性抑郁症 (BDD),30名患有严重抑郁症 (MDD) 的患者和25名健康对照者 (HC) 中测量了血清内分泌水平.
- 参与者是非吸烟者,没有并发性炎症疾病.
- 抑郁症的严重程度使用汉密尔顿抑郁症评分表 (HDRS) 进行评估.
主要成果:
- 血清内分泌水平在BDD患者中明显高于MDD患者和HC患者 (p < .000).
- 此外,MDD患者的内分泌水平明显高于HC患者 (p < .000).
- 恩多坎的诊断准确度很高 (AUC为0.990),可以将抑郁症与对照区分开来,灵敏度为98.4%,特异性为100%.
结论:
- 血清内分泌水平升高表明BDD和MDD患者的内皮损伤.
- 与MDD相比,BDD中的更高的内分泌水平可能表明双相情感障碍中更明显的内皮功能障碍.
- 恩多坎显示出作为与抑郁症相关的内皮损伤的敏感和特定生物标志物的潜力.
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