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Updated: Jul 20, 2025

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在内皮细胞中RNA结合蛋白GIGYF2的异常过度表达调节了血管衰老和功能

Fanglin Niu1, Zhuozhuo Li1, Yuanyuan Ren1

  • 1Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, School of Medicine, Northwest University, Xi'an, Shaanxi, 710069, PR China.

Redox biology
|July 30, 2023
PubMed
概括

与 Grb10 相互作用的 GYF 蛋白 2 (GIGYF2) 通过增强 STAU1 mRNA 稳定性,激活 mTORC1 信号,并促进内皮细胞衰老来驱动血管衰老. 准这种GIGYF2-STAU1-mTORC1通路为心血管疾病提供了潜在的治疗方法.

关键词:
内皮细胞衰老 细胞衰老内皮质功能障碍 内皮质功能障碍信号传输 信号传输血管的衰老 血管的衰老在eNOS解时.

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