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(Vaccinium myrtillus) 提取物对X射线辐射诱导的视网膜毒性的保护作用,通过eNOS和8-OHdG表达

Hüseyin Fındık¹, Mehmet Gökhan Aslan¹, Murat Okutucu¹

¹Department of Ophthalmology, Recep Tayyip Erdogan University, Rize, Turkey.

Cells, tissues, organs

|July 30, 2023

概括

(Vaccinium myrtillus) 提取物保护了老鼠视网膜组织免受X射线辐射损伤. 这种抗氧化疗法降低了氧化应激标志物,并逆转了辐射诱导的细胞损失,表明其作为辐射视网膜病变的辅助治疗的潜力.

科学领域:

眼科医生眼科眼科
辐射瘤学辐射瘤学
药理学药理学是指药理学的学科.

背景情况:

癌症的放射治疗可以诱导健康组织的氧化应激,包括视网膜.
辐射诱导的视网膜病变是接受放射治疗的患者的一个重大问题.

研究的目的:

调查Vaccinium myrtillus (白,WB) 提取物对X射线辐射诱导的视网膜损伤的保护作用.
评估WB提取物作为辐射视网膜病变的潜在辅助疗法.

主要方法:

斯普拉格-道利大鼠被暴露在8个灰色 (Gy) X射线辐射中,并用100毫克/公斤或200毫克/公斤WB提取物进行10天内内治疗.
进行了组织病理学,免疫组织化学 (8-基-2'-脱氧氨素 [8-OHdG],内皮氧化合成酶 [eNOS]) 和生物化学 (氨过氧化酶 [GSH],氨 [MDA]) 分析.

主要成果:

X射线照射显著降低了GSH水平,增加了MDA和8-OHdG染色,表明氧化应激和DNA损伤.
WB提取物治疗显著增加了GSH,减少了MDA和8-OHdG,并逆转了视网膜层中辐射诱导的细胞损伤.
随着WB治疗,eNOS染色和整体细胞损失/明显改善.

结论:

(Vaccinium myrtillus) 提取物显示出对大鼠X射线辐射诱导的视网膜损伤有显著的保护作用.
黄提取物可以作为一种有价值的辅助疗法,以减轻辐射视网膜病变及其相关视力障碍.

关键词:

内氧化合成酶是内皮氧化合成酶.氧化应激是一种氧化应激.辐射疗法辐射疗法视网膜病变是一种视网膜病变.这种植物是 Vaccinium myrtillus.

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