相关实验视频
Updated: Jul 20, 2025

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Murine Fetal Echocardiography
Published on: February 15, 2013
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在患有先天性细胞巨乳病毒感染的胎儿心肌功能
Veronica Giorgione1,2, Karina Krajden Haratz3, Ilan Gull3
1Division of ObGyn Ultrasound, Lis Maternity and Women's Health Hospital, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, giorgione.veronica@gmail.com.
Fetal diagnosis and therapy
|July 30, 2023
概括
胎儿的先天性细胞巨乳病毒 (CMV) 感染导致亚临床双心室肌肉功能障碍. 二维斑点跟踪回声心电图 (2D-STE) 可以识别这些有潜在心血管问题的风险胎儿.
科学领域:
- 心脏病学 心脏病学
- 胎儿医学 胎儿医学
- 传染性疾病 传染性疾病
背景情况:
- 先天性细胞巨乳病毒 (CMV) 感染是胎儿发育的一个重大问题.
- 具有先天性CMV的胎儿的心肌变形需要进一步调查.
- 二维斑点追踪回声心电图 (2D-STE) 提供了一种非侵入性方法来评估心脏功能.
研究的目的:
- 调查与或没有先天性CMV感染的胎儿的左心室 (LV) 和右心室 (RV) 心肌变形.
- 利用2D-STE量化受影响和未受影响胎儿的心肌应变.
- 为了比较有或没有垂直CMV传播的胎儿之间的心脏指数.
主要方法:
- 一个前性单中心研究,涉及已确认患有先天性CMV的胎儿 (第一组) 和对照 (第二组).
- 垂直CMV传播通过阳性CMV聚合酶链反应 (PCR) 在羊水或新生儿尿液中定义.
- 使用2D-STE测量LV和RV全球纵向应变 (GLS) 值,并根据妊娠年龄 (Z-score) 进行调整.
主要成果:
- 与对照组相比,患有先天性CMV的胎儿 (第1组,n=11) 呈现出明显较低的LV心肌缩短 (第2组,n=32).
- 在第一组 (-20.7 ± 5.2%) 和第二组 (-26.3 ± 4.1%) (p=0.001) 中,LV GLS显著降低.
- 在患有先天性CMV的胎儿中,LV和RV GLS Z-score均显著受损,表明亚临床双心脏功能障碍.
结论:
- 先天性CMV感染与胎儿的亚临床双心室肌动脉功能障碍有关.
- 2D-STE显示出识别具有先天性CMV风险的胎儿的潜力,这些胎儿有出生后心血管并发症的风险.
- 需要进一步的研究来验证2D-STE在管理先天性CMV相关心脏风险方面的作用.
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