相关实验视频

Updated: Jul 20, 2025

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

新生儿早期或晚发性败血症 - 改变范式的时候了吗?

Neal Russell¹, Mikhail Barday², Uduak Okomo³

¹Centre for Neonatal and Paediatric Infection (CNPI), Institute of Infection & Immunity, St George's University of London, London, UK.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

|July 30, 2023

概括

对于新生儿败血症,传统的早期发作的败血症 (EOS) 和晚期发作的败血症 (LOS) 的分类可能不适合低收入和中等收入国家. 病原体的频谱因收入设置而异,这挑战了EOS/LOS范式的普遍适用性.

科学领域:

新生儿医学新生儿医学
传染性疾病传染性疾病
全球健康全球健康

背景情况:

根据高收入环境的数据,新生儿败血症传统上被分为早期发作的败血症 (EOS) 和晚期发作的败血症 (LOS).
来自全球不同环境的越来越多的微生物学数据挑战了这种传统分类的普遍适用性.
病原体频谱和感染时间的差异需要重新评估新生儿败血症分类.

研究的目的:

对住院新生儿中EOS和LOS病因学的文献进行审查.
根据国家收入水平对病原体谱进行分层:低收入 (LIC),中等收入 (MIC) 和高收入 (HIC).
在不同的全球环境中批判性地评估"EOS与LOS"范式的持续适当性.

主要方法:

在PubMed进行了全面的文献搜索,寻找同行评审的全文英语文章.
搜索涵盖了从数据库创建到2022年8月8日的出版物.
分析的重点是研究报告病原体分布在同一医院环境内,无论是EOS和LOS.

主要成果:

在LIC,MIC和HIC设置之间观察到败血症病因的显著差异.
在LIC和MIC中,Klebsiella pneumoniae显示越来越重要,而B组链球菌的重要性在前72小时内下降.
只有49篇原始文章报告了同一家医院中EOS和LOS的病原体分布.

结论:

"EOS与LOS"范式在LIC和MIC设置中预测新生儿败血症病原体谱方面可能不那么有用.
现有的数据挑战了低收入和中等收入国家普遍存在的EOS/LOS范式的概括性.
未来的报告应采用STROBE-NI的指导方针,详细说明新生儿时期的感染时间和病原体谱的变化.

关键词:

一个病因学.抗生素抗生素是一种抗生素.早期发病的早期发病.晚期发病晚期发病新生儿新生儿新生儿败血症这是一种败血症.

更多相关视频

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis

Published on: January 27, 2019

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

相关概念视频

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

Pneumonia I: Introduction

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...