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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
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相关实验视频

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An in vivo Assay to Test Blood Vessel Permeability
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在EPR效应中准内皮质透性.

Behnaz Lahooti1, Racheal G Akwii1, Fatema Tuz Zahra1

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

Journal of controlled release : official journal of the Controlled Release Society
|July 30, 2023
PubMed
概括

由瘤血管和微环境驱动的增强透性和保留 (EPR) 效应有助于纳米药物输送. 了解血管透性的内皮调节对于抗癌疗法的临床转化至关重要.

关键词:
药物输送是药物输送的过程.EPR 效应的产生.纳米颗粒 纳米颗粒透性 透性的瘤是一个瘤.

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科学领域:

  • 在瘤学瘤学.
  • 纳米医学是一种纳米医学.
  • 血管生物学 血管生物学

背景情况:

  • 增强的透性和保留 (EPR) 效应对于提供抗癌纳米药物至关重要,特别是在临床前模型中.
  • 瘤血管的血管透性增加是驱动EPR效应的关键特征.
  • 血管透性的内皮调节对于理解和利用EPR效应至关重要.

研究的目的:

  • 在纳米药物输送的背景下,审查血管透性的内皮调节.
  • 讨论在临床转化中针对血管透性的挑战和机会.
  • 总结机制,媒介和纳米粒子设计,以改善治疗结果.

主要方法:

  • 关于内皮透性,瘤微环境和纳米药物输送的当前文献的综述.
  • 对信号通路和调节血管透性的结构部件的分析.
  • 针对性方法,免疫细胞相互作用和纳米粒子设计的批判性评估.

主要成果:

  • 内皮细胞及其信号通路显著影响血管透性.
  • 透瘤的免疫细胞及其与瘤血管的相互作用会影响纳米医药的输送.
  • 目前的有针对性的方法在临床转化方面面临挑战,需要改进纳米粒子设计.

结论:

  • 针对血管透性的内皮调节具有提高纳米药物输送的前景.
  • 克服挑战需要全面了解瘤微环境和免疫相互作用.
  • 优化纳米粒子设计对于成功的临床转化基于EPR的疗法至关重要.