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与Marvelon相比,Ding-kun-dan对原发性更年障碍的效果:一个前性,双盲,多中心,随机对照试验

Jingwen Gan¹, Shi-Yang Zhu¹, Xiao Ma¹

¹National Clinical Research Center for Obstetric & Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeAddress: Peking Union Medical College Hospital (East), No.1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

Journal of ethnopharmacology

|July 30, 2023

概括

丁昆丹 (DKD) 提供了一种有效和安全的替代方案来缓解原发性经期障碍 (PD) 的症状,在第12周之前显示出与Marvelon相似的疗效. 这种传统中医药特别适用于轻度疼痛和避免荷尔蒙治疗的人.

科学领域:

妇科妇科医生妇科
药理学药理学是指药理学的学科.
传统中国医药传统中国医药

背景情况:

丁昆丹 (Ding-kun-dan,DKD) 是一种传统中医药 (TCM),以调节月经和改善气和血液而闻名.
之前的研究表明,在动物模型中,DKD对PCOS和子宫内膜异位症等疾病的潜力很大,但对原发性失调症 (PD) 的临床数据有限.

研究的目的:

为了比较Ding-kun-dan (DKD) 与Marvelon在缓解原发性更年障碍症状方面的疗效.
为了评估血清疼痛相关因素的变化,包括PGF2a,PGE2和NO,在PD患者治疗DKD或Marvelon.

主要方法:

一项随机试验涉及136名患有原发性经期障碍的患者,被分配到DKD或Marvelon组.
治疗包括每天给药10天 (DKD) 或21天 (Marvelon) 每28天在12周期间.
使用视觉模拟尺度 (VAS),中国月经痛苦问卷 (CMSS) 和PGF2a,PGE2和NO的血清水平来评估治疗效果.

主要成果:

无论是DKD还是Marvelon都有效地减少了疼痛和相关症状. 在降低VAS和CMSS分数方面,Marvelon最初表现出优势.
随着时间的推移,疗效差距逐渐缩小,到第12周,DKD显示对Marvelon的非劣势性.
在降低PGF2a,PGE2和NO水平方面,DKD的疗效与Marvelon相当,两种治疗都没有报告严重的不良反应.

结论:

丁昆丹 (DKD) 是一种可行,有效和安全的治疗方案,用于治疗初级经期障碍.
特别推给患有轻度疼痛或对荷尔蒙疗法有禁忌的患者使用.

关键词:

在CMSS中使用CMSS 丁 - 昆 - 丹是什么意思漫威和漫威公司 PGE ((2)) 的情况.在PGF中{2a)对于PGF{2a) /PGE{2b) 来说,这是一个很好的选择.原发性经期障碍 - - 主要的经期障碍.这就是VAS VAS.

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Blinding

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.