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Updated: Jul 20, 2025

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry
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对一种细菌腺索基巴胺依赖突变酶的G蛋白伴侣介导成熟的结构洞察

Francesca A Vaccaro1, Daphne A Faber2, Gisele A Andree1

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

The Journal of biological chemistry
|July 30, 2023
PubMed
概括

像ICMF这样的G蛋白辅助体使用GTP水解来成熟金属酶,通过输送腺可巴胺 (AdoCbl) 或去除损坏的可巴胺 (Cbl). 这一过程涉及ICMF寡合化和构造变化,从而打开突变酶活性部位.

关键词:
这是一个GTPase.腺基巴胺 (AdoCbl) 是一种陪伴者是一个陪伴者.提供辅助因素的交付.冷电子显微镜的使用方法成熟 成熟 成熟 成熟.这是一种金属酶 (metaloenzyme).

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