相关实验视频
Updated: Jul 20, 2025

10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
12.2K
聚合菌Actinomycetemcomitans与牙周炎和类风湿性关节炎有关
Yizhi Huang1, Su Ni2
1Department of Stomatology, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, 29 Xinglong Alley, Changzhou 213003, PR China.
International dental journal
|July 30, 2023
概括
聚合菌Actinomycetemcomitans感染与类风湿性关节炎 (RA) 患者的较高疾病活性有关,特别是那些患有牙周炎 (PD) 患者. 这表明这种细菌在RA和PD发展中可能发挥作用.
科学领域:
- 口腔微生物学 口腔微生物学
- 类风湿病学 类风湿病学
- 牙周病学 牙周病学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病.
- 牙周炎 (PD) 是一种常见的口腔炎症疾病.
- 特定的口腔细菌与RA疾病活性之间的关联是正在进行的研究领域.
研究的目的:
- 调查Aggregatibacter actinomycetemcomitans (A actinomycetemcomitans) 感染和中国风湿性关节炎 (RA) 患者的疾病活性之间的关系.
- 探索这种关联在RA患者和没有牙周炎 (PD).
主要方法:
- 进行了一项病例控制研究,涉及115名RA患者 (67名仅RA,48名RA+PD).
- 使用斯皮尔曼相关性分析来评估Aactinomycetemcomitans阳性和RA/牙周指标之间的相关性.
- 数据是在2017年11月至2019年3月期间收集的.
主要成果:
- 在RA+PD患者中,与RA患者相比,Actinomycetemcomitans的阳性显著更高 (P = .007).
- 关节炎疾病活性指标 (DAS28,RF,抗CCP,APAb) 与Aactinomycetemcomitans阳性正相关 (P范围:0.002.041).
- 一个actinomycetemcomitans的阳性与探测口袋深度 (P = .027) 和牙指数 (P = .043) 相相关,但不是斑块指数,CAL或BOP.
结论:
- 聚合菌Actinomycetemcomitans感染可能与类风湿性关节炎患者的牙周炎的发展有关.
- 研究结果表明,口腔细菌与RA病变发生之间存在潜在的联系.
相关概念视频
Genome-wide Association Studies-GWAS
13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.6K
The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
Rheumatic Heart Disease I: Introduction
16
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
16
Bacterial Phylum Actinobacteria
36
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
36
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38

