一个不断变化的肠道病毒生态景观,寿命长
Tomasz Wilmanski1, Sean M Gibbons2
1Amgen, Inc., Thousand Oaks, CA 91320, USA.
Trends in microbiology
|July 30, 2023
概括
人的肠道病毒组合随着年龄的增长而变化. 核心病毒种群的数量下降,次主导种群的数量增加,反映了老年人肠道细菌的变化.
科学领域:
- 微生物学 微生物学
- 老年学是一门学科.
- 病毒学 病毒学
背景情况:
- 人的肠道微生物组,包括病毒 (病毒组),在健康方面发挥着至关重要的作用.
- 对细菌来说,与年龄相关的肠道微生物组变化已被充分记录,但对病毒组的了解较少.
研究的目的:
- 为了研究人类肠道病毒组的生态组成的与年龄相关的变化.
- 为了比较病毒社区的动态与已知的细菌变化在老龄化个体.
主要方法:
- 从不同年龄组的队列中分析肠道病毒样本.
- 生物信息分析以评估病毒种群的丰富性和多样性.
主要成果:
- 随着年龄的增长,核心病毒类型的丰富性显著下降.
- 在老年人中,相应的亚主导病毒类型的丰富.
- 观察到的病毒组成变化与之前报告的肠道细菌组的变化并行.
结论:
- 人的肠道病毒组在整个生命周期中经历了显著的生态重组.
- 衰老影响肠道微生物组的细菌和病毒组成部分.
- 这些发现有助于理解病毒在衰老和与年龄相关的健康中的作用.
更多相关视频
08:14A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
Published on: February 28, 2018
8.9K
06:56Preparing and Rearing Axenic Insects with Tissue Cultured Seedlings for Host-Gut Microbiota Interaction Studies of the Leaf Beetle
Published on: October 8, 2021
2.5K
相关概念视频
Bacterial Flora of the Large Intestine
516
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
516
Anatomy of the Intestines
72.5K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.5K
Physiology of Enteric Nervous System and Gut Health
312
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
312
