在儿童的 Pseudomonas aeruginosa bacteremia 中死亡的风险因素
Jian Chen1, Haixin Huang1, Chengjun Liu1
1Department of Critical Care Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
在儿童中,Pseudomonas aeruginosa bacteremia是一种严重的医院感染. 呼吸衰竭和肝功能障碍显著增加了这些儿科患者60天死亡的风险.
科学领域:
- 儿童传染病 儿童传染病
- 临床微生物学 临床微生物学
- 医院流行病学 医院流行病学
背景情况:
- Pseudomonas aeruginosa (P. aeruginosa) 细菌病是儿童格兰阴性细菌感染的重要原因,在发病率上排名第三至第四.
- 它是医院环境中常见的机会性病原体,对脆弱的儿科患者群体构成相当大的威胁.
研究的目的:
- 为了研究被诊断患有P. aeruginosa bacteremia的儿童的临床特征.
- 在这个患者群体中确定与60天住院死亡率相关的独立风险因素.
主要方法:
- 从2015年1月到2021年12月,在一家三级儿科医院进行了一项回顾性研究.
- 卡普兰-梅尔生存分析和后勤回归被用来分析时间到事件的结果和死亡率的风险因素.
主要成果:
- 在75名患有P. aeruginosa细菌病的儿科患者中,常见的潜在疾病包括免疫抑制 (52%),中性质减退 (50.7%) 和血液恶性瘤 (48%).
- 观察到的显著并发症包括败血性休克 (33.3%),呼吸衰竭 (40%) 和肝功能受损 (26.7%).
- 在60天的住院死亡率为17.3%. 死亡的独立风险因素是呼吸衰竭 (OR 39.329) 和肝功能障碍 (OR 17.925).
结论:
- 呼吸衰竭和肝功能受损是儿童P. aeruginosa bacteremia预后不佳的关键指标.
- 这些并发症的早期识别和管理对于改善受影响儿童的生存率至关重要.
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