来自Cordyceps的生物活性化合物及其治疗潜力
Kondapalli Vamsi Krishna1, Rutwick Surya Ulhas2, Alok Malaviya1,3,4
1Applied and Industrial Biotechnology Laboratory, Christ (Deemed-to-be University), Bangalore, Karnataka, India.
Critical reviews in biotechnology
|July 30, 2023
概括
科迪塞普斯真菌含有丰富的生物活性化合物,具有多种治疗益处. 本综述详细介绍了它们的代谢物,包括cordycepin,以及它们对抗微生物,抗癌和免疫调节应用的潜力.
科学领域:
- 菌类学 菌类学是指菌类学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 科迪塞普斯是Clavicipitaceae中最大的属,在全球潮湿的森林中壮成长.
- 它寄生于关节动物,产生超过200种生物活性代谢物.
- 这些化合物具有抗微生物,抗亡,抗癌,抗炎,抗氧化和免疫调节性质.
研究的目的:
- 审查Cordyceps代谢物的生物活性和治疗性质.
- 更新有关Cordyceps spp.的现有文献.
- 详细介绍康迪塞的生物合成,机制和药理作用.
主要方法:
- 关于Cordyceps spp. 的文献评论 代谢物及其生物活性.
- 专注于cordycepin的生物合成,保护者-受保护者机制和生物效应.
- 基于植物化学成分的治疗潜力的分析.
主要成果:
- 科尔迪塞普斯种类. 产生各种各样的代谢物,如核酸,多糖和固醇.
- 这些代谢物表现出广泛的药理活性.
- 科迪塞在调节细胞亡和细胞循环方面表现出潜力,并抑制核酸生物合成.
结论:
- 科尔迪塞普斯种类. 由于其丰富的代谢物配置,它们具有显著的生物活性潜力.
- 康迪塞是一种关键化合物,具有有前途的治疗应用.
- 对Cordyceps代谢物的进一步研究可能会导致新药的开发.
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