长期暴露于温暖的温度会导致Drosophila melanogaster的精子丰度和质量低下
Ana Caroline P Gandara1,2, Daniela Drummond-Barbosa3,4
1Department of Genetics, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Scientific reports
|July 30, 2023
概括
暴露在高温 (29°C) 的雄性果由于精子数量和质量降低而变得不育. 精子在精液囊之前被清除,幸存的精子无法支持早期胚胎发生.
科学领域:
- 生殖生物学 生殖生物学
- 环境生理学环境生理学
- 德洛索菲拉黑虫研究 研究 科研
背景情况:
- 男性的生育能力对温度敏感,但对成年精子生成的影响还未得到充分研究.
- 温暖的温度 (29°C) 极大地降低了Drosophila melanogaster的男性生育能力.
研究的目的:
- 在温暖的温度下 (29°C) 调查Drosophila melanogaster中男性不孕症的原因.
- 确定低于最佳温度对精子丰富度,质量和精子生成的影响.
主要方法:
- 在控制 (25°C),温暖 (29°C) 和寒冷 (18°C) 温度下对雄性果进行比较分析.
- 评估生殖系干细胞和精子细胞的数量.
- 对精子长和个性化缺陷的评估.
- 精子丰富度和质量评估,包括受精和胚胎发育测试.
主要成果:
- 在29°C的温度下,由于精子的数量和质量较低,男性表现出不孕不育.
- 胚胎干细胞和精子细胞的数量在29°C时不受影响.
- 精子细胞延长和个性化缺陷在18°C和29°C时都会增加,但在18°C时不会导致不孕.
- 精子丰富度在29°C时突然下降,没有证据表明有亡,这表明一种未知的消除机制.
- 来自29°C男性的精子显示受精效率降低和胚胎发育支持.
结论:
- 在29°C的男性不孕症是由精子丰富度减少和精子质量受损引起的.
- 在Drosophila melanogaster中,精子生成能容忍某些延长和个性化缺陷.
- 一个未知的机制在高温成熟期间消除精子.
相关概念视频
Background and Environment Affect Phenotype
6.6K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.6K
Spermatogenesis
102.7K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.7K


