在COVID-19之前和期间,对慢性鼻炎的抗生素敏感性测试的细菌学研究
D Irfandy1, A Hafiz2, B J Budiman2
1Division of Rhinology, Otorhinolaryngology Department, Faculty of Medicine-Universitas Andalas/ Dr. M. Djamil General Hospital Padang, Indonesia. dollyirfandy@med.unand.ac.id.
慢性鼻炎 (CRS) 的抗生素耐药性在COVID-19大流行期间发生了变化. 斯塔菲洛科克斯 (Staphylococcus epidermidis) 成为占主导地位的细菌,对西普罗夫洛克萨的耐药性显著增加.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 慢性鼻炎 (CRS) 影响5-12%的人口,严重影响生活质量.
- 抗生素是CRS的主要治疗方法,但抗生素耐药性增加使管理复杂化.
- 了解细菌模式和耐药性对于有效的CRS治疗和预防进一步的耐药性至关重要.
研究的目的:
- 在COVID-19大流行之前和期间确定导致CRS的细菌模式.
- 分析CRS患者抗生素耐药性模式的变化.
- 引导适当使用抗生素,防止抗药性升级.
主要方法:
- 在RSUP Dr. M. Djamil Padang. 在2016-2021年期间对174名CRS患者的回顾性研究.
- 从医疗记录中分析培养和敏感性测试数据.
- 包括接受手术并接受抗生素治疗的患者.
主要成果:
- 在COVID-19后,CRS与息肉的患病率略有下降,从63.8%降至60%.
- 在COVID-19之前,金黄色葡萄球菌是占主导地位的病原体 (39-44%),在大流行期间被 Staphylococcus epidermidis (50%) 代替.
- 对阿莫西西林-克拉夫兰酸 (75-100%) 的高耐药性持续存在,在COVID-19后的西普罗夫洛克萨耐药性 (56-100%) 显著增加.
结论:
- 在COVID-19大流行期间,CRS患者发生了细菌模式和抗生素耐药性的显著变化.
- 这些变化需要仔细监测和战略性抗生素使用,以对抗日益增长的耐药性.
- 需要紧急关注,以解决在CRS管理中不断发展的抗生素耐药性趋势.
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