可治疗的特征,组合吸入器治疗和喘管理的未来
Peter G Gibson1,2, Vanessa M McDonald1,2, Dennis Thomas1
1Centre of Excellence in Treatable Traits, College of Health, Medicine and Wellbeing, University of Newcastle, Hunter Medical Research Institute Asthma and Breathing Program, Newcastle, New South Wales, Australia.
概括
尽管喘药物和吸入器设备取得了进展,但不受控制的喘仍然存在. 个性化医疗和可治疗的特征为优化喘管理提供了未来,解决了坚持和疾病异质性的问题.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 个性化医疗是个性化的医疗.
背景情况:
- 喘管理在新的药物和吸入器设备方面取得了进步.
- 然而,很大一部分患者仍然患有不受控制的喘.
- 这往往是由于药物/设备的使用不正确,疾病异质性或其他有助于的因素.
研究的目的:
- 审查目前个性化药物和喘中联合吸入器治疗的现状.
- 探索未来的战略,以优化喘管理.
- 突出结合吸入器治疗和可治疗特征 (TTs) 的互补性.
主要方法:
- 关于喘药物治疗和治疗指南的当前文献的综述.
- 对个性化医疗方法的分析,包括可治疗特征 (TTs).
- 讨论新兴技术,如智能吸入器和超长效药.
主要成果:
- 吸入性皮质类固醇 (ICS) 有或没有长效β激动剂 (LABA) 是当前喘管理的核心.
- 现在,即使在轻度喘中,也建议使用组合吸入器治疗 (ICS/LABA).
- 包括TT方法在内的个性化医学正在发展,以解决疾病的复杂性和提高治疗质量.
结论:
- 组合吸入器治疗和TTs方法是控制喘的互补策略.
- 未来的治疗可能包括超长效应的个性化药物和智能吸入器,以提高坚持和技术.
- 转向精准医学的转变承认喘是一种多方面的疾病,需要量身定制的治疗.
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