相关实验视频
Updated: Jul 20, 2025

Intraportal Transplantation of Pancreatic Islets in Mouse Model
Published on: May 5, 2018
胰腺外分泌和胰腺移植后体重增加
Amanda Van Jacobs1, Michael D Williams1, Oliver G Ralph1
1Department of Surgery, University Transplant Program, Rush University Medical Center, Chicago, IL, USA.
胰腺移植接受者经历了显著的体重增加和超正常的便弹性酶水平,但这两个因素没有相关性. 需要进行更多的连续测量研究,以了解移植后的体重变化.
科学领域:
- 移植科学 移植科学
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
背景情况:
- 体重增加是胰腺移植后常见但不太了解的并发症.
- 潜在的原因包括胰岛素产量增加,免疫抑制和食欲变化.
- 外分泌功能在移植后体重增加中的作用以前没有被研究过.
研究的目的:
- 为了研究胰腺移植后便弹性酶-1 (FE-1) 水平的变化.
- 为了确定FE-1水平是否与移植后体重增加相关.
- 确定与胰腺移植接受者的体重变化相关的其他因素.
主要方法:
- 一项前性研究包括42名接受胰腺或联合胰腺-脏移植的患者.
- 便弹性酶-1 (FE-1) 测量在一个时间点;水平>500μg/g被认为是高.
- 收集了体重和C-值;所有患者都接受了无类固醇免疫抑制.
主要成果:
- 近一半 (45%) 的患者表现出超正常的FE-1水平 (>500μg/g).
- 移植后3年观察到体重增加的中位数为14%,最显著的增加发生在1年和2年之间.
- 体重增加和FE-1水平,移植前C或糖尿病持续时间之间没有发现相关性.
结论:
- 胰腺移植与表皮功能 (超正常FE-1) 的增加和显著的体重增加有关.
- 尽管有这些同时发现,外分泌功能似乎与这一队列的体重增加没有直接关联.
- 需要进行长度研究,在移植前和移植后连续测量FE-1,以阐明与体重变化的关系.
更多相关视频
07:44Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation
Published on: August 7, 2015
10:43Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
Published on: October 31, 2007
相关概念视频
Chronic Pancreatitis II: Collaborative Care
Assessment:
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion
Insulin and C-peptide are...
Insulin Secretory Vesicles
Cells and Secretions of the Pancreas
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
Pancreatic Juice and Secretion
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...