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卢拉西和卡里普拉辛的认知影响:一个小型系统性审查
Miriam Olivola1,2, Nicola Bassetti1, Serena Parente1
1Department of Brain and Behavioral Sciences, Università di Pavia, Pavia, 27100, Italy.
Current neuropharmacology
|July 31, 2023
概括
卢拉西和卡里普拉辛在改善精神分裂症患者的认知功能方面表现有前途. 这两种药物在动物和人类研究中都表现出有效性,卡里普拉辛在某些方面表现出优越性.
科学领域:
- 神经科学是一个神经科学.
- 心理药理学 心理药理学
- 临床精神病学 临床精神病学
背景情况:
- 认知缺陷是精神分裂症的核心症状,通常会随着时间的推移而恶化,并且对当前的治疗方法有抗性.
- 新型抗精神病机制,包括5-HT7受体对抗性 (卢拉西) 和D3受体部分激动性 (卡里普拉),可能为认知障碍提供新的治疗途径.
研究的目的:
- 系统地审查卢拉西和卡里普拉辛在增强精神分裂症患者认知功能的疗效.
- 为了比较它们在临床前动物模型和人类临床试验中的效果.
主要方法:
- 在Web of Science上进行了一项系统的文献搜索,使用与lurasidone,cariprazine和cognition相关的术语.
- 包括评估任何药物治疗后认知变化的研究,包括动物模型和人类临床试验.
主要成果:
- 卢拉西在动物和人类研究中与安慰剂和其他抗精神病药物相比显示出显著的认知改善.
- 卡里普拉辛在改善两种研究类型的认知功能方面也比其他抗精神病药物表现出优越性.
- 卢拉西的作用可能与5-HT7和5-HT1A受体活性有关,而卡里普拉的作用可能是由于其对D3受体的高度亲和力.
结论:
- 卢拉西和卡里普拉辛都显示出改善精神分裂症认知缺陷的潜力.
- 需要进行进一步的对比研究,以确定卢拉西和卡里普拉津之间的最佳选择,以治疗精神分裂症的认知功能障碍.
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