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母亲的教育和为自愿运动行为进行选择性育种改变了小鼠大脑中DNA甲基化和基因表达的模式

Sarah E Latchney¹, Marcell D Cadney^2,3, Anthony Hopkins⁴

¹Department of Biology, St. Mary's College of Maryland, St. Mary's City, Maryland, USA.

Genes, brain, and behavior

|July 31, 2023

概括

表观遗传变化,特别是DNA甲基化,影响小鼠的运动行为. 母亲的教育和性别也会改变这些表观遗传模式,影响与跑步活动相关的基因表达.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

选择性育种研究练习行为遗传学.
像DNA甲基化这样的表观遗传机制也会导致运动行为.
之前的研究表明,高跑者 (HR) 小鼠的性别特异性DNA甲基化变化以及交叉培养的影响.

研究的目的:

鉴定基因与改变的DNA甲基化和表达,由于选择运行和母亲的教育.
调查与运动行为相关的性别特异性表观遗传修饰.

主要方法:

在小鼠大脑中对14个基因进行了双硫酸盐测序和基因表达测定.
采用了选择性繁殖 (HR与控制C线) 和交叉培养模式.
分析了像海马体和皮质这样的大脑区域的DNA甲基化和基因表达.

主要成果:

发现了Bdnf,Pde4d和Grin2b的DNA甲基化和基因表达的改变.
降低Bdnf甲基化与HR小鼠海马体Bdnf表达增加相关.
交叉培养影响了Pde4d (皮质) 和Grin2b (海马) 的甲基化和表达.
性别影响了Atrx和Oxtr (皮质),Atrx和Bdnf (海马) 的DNA甲基化模式.

结论:

基因甲基化和基因表达的变化与选择的运动行为有关.
早期的生活环境 (母亲的抚养) 与表观遗传修饰相互作用.
性和早期生活因素可能与DNA甲基化相互作用,塑造成人运动行为.

关键词:

在 Bdnf 找通过DNA甲基化.在Grin2bb中使用.在Pde4dd中使用.双硫酸盐序列测序双硫酸盐序列测序脑子脑子脑子大脑交叉养育是什么意思交叉养育循环AMP反应元素结合蛋白质的循环AMP反应元素.运动就是炼身体.遗传选择遗传选择轮子运行 - 轮子运行 - 轮子运行

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