插入偏好对于转体子入侵轨迹的关键作用
Manisha Munasinghe1, Nathan Springer1, Yaniv Brandvain1,2
1Department of Plant and Microbial Biology, University of Minnesota, St. Paul, MN, United States.
Evolution; international journal of organic evolution
|July 31, 2023
概括
移动DNA序列或可转移元素 (TE) 通过插入不那么有害的DNA区域来入侵基因组. 对TEs的宿主抑制对于防止种群灭绝和保持基因组稳定至关重要.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 人口遗传学 人口遗传学
背景情况:
- 移动DNA序列,称为可移植元素 (TE),对宿主基因组构成挑战,因为它们有可能降低宿主适应性.
- 在TE家族入侵的早期,宿主可能缺乏有效的调控机制来控制TE的扩散.
- 转基因必须在基因组内达到稳定的拷贝数量,但促进这一目标的机制,特别是早期的入侵,仍然不清楚.
研究的目的:
- 调查可转移元素 (TE) 插入偏好和转移率如何影响 TE 副本数和宿主群体大小.
- 确定TE入侵可能导致宿主种群灭绝的条件.
- 探索宿主调节和TE插入地点偏好之间的相互作用,以减轻TE扩散的负面影响.
主要方法:
- 使用计算模拟来建模TE入侵和宿主群体演变的动态.
- 模拟改变了TE转移概率和插入部位偏好.
- 人口规模和灭绝事件在不同的监管场景下被跟踪.
主要成果:
- 如果没有宿主抑制,对TEs的中立插入偏好会加速种群灭绝.
- 宿主抑制显著改变了 TE 插入偏好的影响.
- 偏好中性插入地点,加上宿主抑制,最大限度地减少有害影响,并促进宿主群体的生存.
结论:
- TE 插入偏好是 TE 宿主共同进化的关键因素,其影响取决于宿主监管能力.
- 宿主抑制对于减轻与 TE 扩散相关的风险和防止种群灭绝至关重要.
- 偏爱中立插入点的TEs,当由宿主调节时,可以实现更高的副本数量,而不会危及宿主群体的生存能力.
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