细胞还原性手术与高温腹腔内化疗:术后液体在前24小时以后的影响
Yael Berger1, Brianne J Sullivan1, Eliahu Y Bekhor1
1Department of Surgery, Division of Surgical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Journal of surgical oncology
|July 31, 2023
概括
在细胞还原性手术和高温腹腔内化疗 (CRS/HIPEC) 后,限制静脉注射液 (IVF) 给药可能会降低腹腔癌指数低的患者的并发症. 这项研究表明,较低的试管婴儿率与更好的结果有关.
科学领域:
- 手术瘤学手术瘤学
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
背景情况:
- 细胞还原性手术和高温腹腔内化疗 (CRS/HIPEC) 是一个复杂的程序.
- 在CRS/HIPEC后进行外科手术期间静脉注射液 (IVF) 给药,目前还没有确定的指导方针.
- 了解试管婴儿对患者结果的影响至关重要.
研究的目的:
- 评估接受CRS/HIPEC治疗的患者的术后试管婴儿注射和术后发病率之间的关系.
- 为了确定与减少并发症相关的最佳试管婴儿率.
主要方法:
- 从2007年3月至2018年6月接受CRS/HIPEC治疗的185名患者的回顾性审查.
- 根据腹癌指数 (PCI) 分类的患者:低 (<10) 和高 (≥10).
- 试管婴儿体积和类型的分析,在手术期间和手术后72小时内进行,与并发症相关.
主要成果:
- 在低PCI患者中,在术后0-2天的更高的试管婴儿率与整体并发症的增加相关.
- 高水平的手术内试管婴儿与术后第0天的呼吸困扰有关.
- 术后试管婴儿产卵的增加与内脏病和术后第1和第2天的ICU停留时间增加有关.
结论:
- 更高的术后试管婴儿率与接受CRS/HIPEC的低PCI患者的术后发病率增加有关.
- 在CRS/HIPEC后限制试管婴儿的使用可能有助于减少并发症.
- 进一步的研究可能会为这种患者群体建立特定的试管婴儿指南.
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