基于雌激素的激素治疗和COVID-19患者血栓形成的风险
Corinne LaVasseur1, Rick Mathews2, Jenny S H Wang2
1Department of Internal Medicine, Oregon Health & Science University, Portland, Oregon, USA.
European journal of haematology
|July 31, 2023
概括
含有雌激素的治疗显著增加了COVID-19患者,特别是50岁以上患者的静脉血栓栓塞 (VTE) 的风险. 动脉血栓形成风险没有受到雌激素使用的显著影响.
科学领域:
- 在病毒感染期间与激素疗法相关的血栓形成风险.
背景情况:
- 含有雌激素的避孕药和激素替代疗法被广泛使用.
- 这些疗法在COVID-19期间对血栓形成风险的影响尚不清楚.
研究的目的:
- 为了评估COVID-19患者使用含有雌激素的治疗与非雌激素的激素治疗的静脉和动脉血栓形成的风险.
主要方法:
- 一项多中心队列研究包括991名确诊COVID-19的患者.
- 患者被分为接受含有雌激素的激素疗法 (n=466) 或仅使用孕激素/局部治疗 (n=525) 的组.
主要成果:
- 含有雌激素的治疗显著增加了COVID-19后诊断静脉血栓栓塞 (VTE) 的风险 (HR 5.46).
- 与对照组 (0.9%) 相比,接受雌激素治疗的50岁以上患者 (8.6%) 的VTE风险最高.
- 在口服雌激素使用和动脉血栓形成之间没有发现显著的关联.
结论:
- 含有雌激素的疗法与COVID-19患者,特别是老年人中更高的VTE风险有关.
- 这些研究结果支持为使用含有雌激素的疗法治疗的COVID-19患者提供增强的提供者咨询.
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