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慢性鼻炎与鼻的MMP-9和EMMPRIN的表达特征

Spyridon Lygeros¹, Gerasimos Danielides¹, George C Kyriakopoulos²

¹Department of Otorhinolaryngology, School of Medicine, University of Patras, Patras, Greece.

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

|July 31, 2023

概括

矩阵金属蛋白酶-9 (MMP-9) mRNA在具有鼻息肉的慢性鼻炎 (CRSwNP) 中被上调,这表明它在疾病发病过程中的作用. MMP-9可能是CRSwNP的治疗点.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
分子生物学分子生物学
病理学病理学病理学

背景情况:

矩阵金属蛋白酶 (MMPs) 在组织重塑中发挥作用.
具有鼻息肉的慢性鼻鼻炎 (CRSwNP) 涉及显著的组织重塑.
MMP-9和EMMPRIN是细胞外矩阵周转的关键调节剂.

研究的目的:

为了比较MMP-9和EMMPRIN在CRSwNP鼻息肉中的表达与健康的鼻腔粘膜.
调查MMP-9和EMMPRIN在CRSwNP病变发生中的潜在作用.

主要方法:

从37名CRSwNP患者和12名健康对照人群中采集了组织样本.
使用RT-PCR量化了MMP-9和EMMPRIN的mRNA水平.
通过西方斑点分析评估了MMP-9和EMMPRIN蛋白质水平.

主要成果:

与对照组相比,CRSwNP组织中的MMP-9mRNA水平显著更高 (p <0.05).
在CRSwNP中,MMP-9蛋白水平呈现上升趋势,但没有达到统计学意义.
在CRSwNP和对照组之间没有观察到EMMPRIN mRNA或蛋白质水平的显著差异.

结论:

在CRSwNP中增加的MMP-9mRNA表明它与疾病有关.
在MMP-9的mRNA和蛋白质水平之间的差异表明后转录调节.
虽然EMMPRIN没有显著的差异,但其在CRSwNP中的作用需要进一步调查.
MMP-9为CRSwNP提供了潜在的生物标志物和治疗点.

关键词:

矩阵金属蛋白质酶是一种金属蛋白质.鼻腔粘膜中的鼻腔粘膜鼻腔多重体是指鼻腔多重体.鼻炎是一种鼻炎.

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