自闭症回归和暴露于工业化学品:初步观察
Helly Goez1, Charlene C Nielsen2, Sean Bryan3
1Division of Developmental Medicine and Rehabilitation, Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada.
概括
患有回归自闭症谱系障碍 (ASD+R) 的儿童在诊断前一年与没有回归 (ASD-R) 的儿童相比,与特定的工业污染物有更强的联系. 这表明ASD亚型的环境风险因素可能存在差异.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 毒理学 毒理学 毒理学
背景情况:
- 工业污染物暴露是自闭症谱系障碍与回归 (ASD+R) 的研究不足的危险因素.
- 了解环境影响对于区分ASD亚型至关重要.
研究的目的:
- 调查与ASD+R和ASD没有回归 (ASD-R) 的儿童家庭位置相关的工业空气化学物质排放的地理模式.
- 探索ASD+R和ASD-R组之间的暴露时间和化学类型的差异.
主要方法:
- 工业化学品排放的地理分析与被诊断为ASD+R和ASD-R的儿童的住所地址.
- 与诊断相比,在不同的暴露时间窗口中对拼接模式的比较.
主要成果:
- 排放的化学物质中有15种与ASD+R病例有关,而65种与ASD-R病例有关.
- 在诊断前大约一年,ASD+R与特定神经毒剂和免疫毒剂的结合更强.
- 在所有研究的暴露期内,ASD-R与各种化学物质呈现了中度的聚合.
结论:
- 初步发现表明,ASD+R与ASD-R的环境暴露情况不同.
- 污染物暴露模式的差异可能表明ASD亚型之间的潜在病理生理学变异.
- 需要进一步的研究来证实这些与暴露相关的差异及其影响.
相关概念视频
Autism Spectrum Disorder
161
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
161
Toxic Reactions: Overview
1.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.0K
Types of Toxins
1.8K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.8K
Effects of Chemicals: Overview
1.3K
Drugs, encompassing various chemical compounds from natural sources, lab synthesis, or genetic engineering, elicit different biological responses in living organisms. Some of these responses are desirable or therapeutic, while others are undesirable. The primary goal of administering a drug is to achieve a therapeutic effect, that is, to address a specific disease or health condition. Any concurrent effects outside of this therapeutic outcome are considered undesirable. These undesirable...
1.3K


