受阴道出血影响的怀孕与女性死亡率之间的关联:一个队列研究
Elena Dudukina1, Erzsébet Horváth-Puhó1, Henrik Toft Sørensen1
1Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
概括
这项研究发现,与未受影响的怀孕或妊娠结果 (如终止或流产) 相比,怀孕期间阴道出血 (VB) 导致妇女死亡风险没有增加. 这些发现表明,VB与女性的死亡率较高无关.
科学领域:
- 生殖健康 生殖健康
- 孕产妇的死亡率 孕产妇的死亡率
- 流行病学 流行病学
背景情况:
- 怀孕期间的阴道出血 (VB) 是孕妇常见的担忧.
- 了解VB和孕产妇死亡率之间的关联对于公共卫生至关重要.
- 以前的研究可能没有足够地将受VB影响的怀孕与多样化的对照组进行比较.
研究的目的:
- 调查怀孕期间阴道出血 (VB) 与女性死亡率之间的关联.
- 为了比较VB受影响怀孕中的死亡风险与VB不受影响的怀孕,终止和流产.
主要方法:
- 一项使用1979-2017年全国性丹麦登记册的观察性队列研究.
- 包括来自135万名妇女的超过310万例怀孕,包括70,835例受VB影响的怀孕.
- 死亡率和危险比率 (HRs) 被计算并根据混因素进行调整.
主要成果:
- 在所有原因,自然或非自然原因死亡率的统计学上显著增加的风险没有发现VB受影响的怀孕与VB不受影响的怀孕相比,在敏感性分析 (1994-2017) 中.
- 受到VB影响的怀孕后的死亡率并不明显高于终止或流产后的死亡率.
- 最初的分析显示,受VB影响的怀孕的死亡风险略有增加,但在后来的数据中,这种情况得到了减弱.
结论:
- 该研究没有发现证据支持怀孕期间阴道出血与女性死亡风险增加有关.
- 与其他妊娠结果相比,怀孕期间的阴道出血似乎与较高的死亡率无关.
- 这些发现有助于更好地了解妊娠并发症和母亲健康结果.
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