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相关概念视频

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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相关实验视频

Updated: Jul 20, 2025

Proteomic Analysis of Human Macrophage Polarization Under a Low Oxygen Environment
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Proteomic Analysis of Human Macrophage Polarization Under a Low Oxygen Environment

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异常减少巨细胞ALKBH5表达导致异常偏振,并抑制骨质细胞分化.

Junquan Weng1,2,3, Haidong Fan1,2,3, Huijuan Liu1,2,3

  • 1Department of Stomatology, Shenzhen People's Hospital, Shenzhen 518020, Guangdong, China.

Stem cells international
|July 31, 2023
PubMed
概括
此摘要是机器生成的。

糖尿病周植入炎涉及M1巨细胞两极分化和减少ALKBH5表达,阻碍骨修复. 抑制ALKBH5可能为这种疾病提供新的治疗策略.

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Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
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相关实验视频

Last Updated: Jul 20, 2025

Proteomic Analysis of Human Macrophage Polarization Under a Low Oxygen Environment
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科学领域:

  • 口腔和牙面部外科手术
  • 免疫学 免疫学 免疫学
  • 内分泌学 在内分泌学.

背景情况:

  • 牙周植入物炎,牙植入物周围的炎症,导致恢复失败.
  • 患有植入周炎的糖尿病患者经历了复杂的骨质损失.
  • 导致持续性糖尿病周植入炎的机制尚不清楚.

研究的目的:

  • 研究M1巨分化在糖尿病周植入炎中的作用.
  • 确定糖尿病周植入炎进展的关键分子调节剂.
  • 探索ALKBH5在骨质分化和围植入炎中的功能.

主要方法:

  • 在糖尿病和非糖尿病周植入炎模型中对M1巨分化进行比较分析.
  • RNA测序以识别差异表达的基因,重点是ALKBH5.5.
  • 关于ALKBH5,m6A修饰和介酶干细胞骨质分化的机制研究.

主要成果:

  • 在糖尿病周植入炎中,异常的M1巨分化显著增强.
  • RNA测序显示,在糖尿病周植入炎中ALKBH5表达显著降低.
  • 发现ALKBH5及其介导的m6A修饰会影响骨质分化.

结论:

  • M1巨分化和ALKBH5表达的减少有助于在糖尿病周植入炎中抑制骨质母细胞.
  • 在这种情况下,ALKBH5在调节骨质生分化的过程中起着至关重要的作用.
  • 抑制ALKBH5是一种潜在的治疗策略,可以促进骨代谢和治疗糖尿病周植入炎.