口腔癌中的HPV感染,我们的经验:西班牙的流行率,临床影响和当前的疫苗接种计划
Íñigo Aragón-Niño1, Carolina Cuesta-Urquía1, Javier González-Martín-Moro2
1Medical Resident. Oral and Maxillofacial Surgery Department. La Paz University Hospital. Madrid, Spain.
Journal of clinical and experimental dentistry
|July 31, 2023
概括
人类乳头瘤病毒 (HPV) 感染是口腔状细胞癌的负预后因素,表明生存率下降. 建议增加HPV测试和改善疫苗接种计划,以预防口腔癌.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 口腔癌是一个重要的全球健康问题,烟草,酒精和高风险的人类乳头瘤病毒 (HPV) 类型16和18是关键风险因素.
- 虽然HPV与口腔癌有关,但其在口腔状细胞癌 (OSSC) 的预后价值尚不清楚.
- 现有的研究通常将口腔癌数据与更广泛的头癌统计数据相结合,限制了对口腔癌的具体见解.
研究的目的:
- 审查有关口腔癌的最新文献,将其与口腔癌区分开来.
- 在5年内调查口腔癌患者中HPV感染的流行率.
- 评估和比较西班牙的HPV预防计划与其他欧洲国家的HPV预防计划.
主要方法:
- 关于口腔癌和HPV的最新出版物的文献综述.
- 对口腔癌患者HPV患病率的回顾性观察性研究.
- 国家和欧洲HPV预防策略的比较分析.
主要成果:
- 文献综述表明,HPV阳性OSSC与显著减少的整体存活率和远程控制有关.
- 在OSSC中,HPV感染被认为是负面预后因素.
- 西班牙的HPV疫苗接种覆盖率低于欧洲平均水平,需要扩大计划.
结论:
- 建议在OSSC病例中进行广泛的HPV诊断测试,特别是那些具有危险因素的病例.
- 西班牙目前的HPV疫苗接种计划需要扩展,包括追赶策略,以改善覆盖率.
- 需要进一步的研究来澄清HPV在口腔癌中的确切作用和影响.
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