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在口腔下粘膜纤维化中的巨细胞表达:系统性审查和元分析

Harshkant Gharote¹, Rahul Bhowate²

¹Professor, Oral Sciences Division, Dentistry Program, Batterjee Medical College, Jeddah, Saudi Arabia.

Journal of clinical and experimental dentistry

|July 31, 2023

概括

口腔膜纤维化 (OSMF) 涉及瘤细胞数量的增加,尽管随着疾病的进展,这些细胞数量会减少. 需要进一步的研究,以了解巨细胞的作用,并为这种潜在的恶性疾病开发向治疗方法.

科学领域:

口腔病理学口腔病理学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

口腔膜纤维化 (OSMF) 是一种慢性,潜在的恶性口腔疾病.
OSMF的特点是口腔开口减少和灼热感.
巨细胞在OSMF病原发生中的作用受到争论.

研究的目的:

审查巨细胞在OSMF中的作用.
评估OSMF中巨细胞计数 (MCC),脱粒化和免疫组织化学特征.
确定OSMF的潜在治疗点.

主要方法:

在PubMed,EBSCOhost和谷歌学者的综合文献搜索.
包括来自26项已识别的研究的15篇文章.
单个研究数据的综合和巨细胞计数的元分析.

主要成果:

与对照人群相比,在OSMF观察到杆细胞计数 (MCC) 的增加.
随着OSMF阶段的进展,MCC的下降被注意到.
分析揭示了异质性,一些研究表明OSMF中MCC减少.

结论:

乳腺母细胞在OSMF中确实增加,但在晚期阶段,它们的数量会下降.
需要进一步的研究来阐明乳腺细胞参与纤维化的确切机制.
建议在OSMF治疗中研究向乳腺细胞通路的药物试验.

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