创伤后应激障碍,抑郁症和加速衰老:护士健康研究II中的白细胞端粒长度
Andrew Ratanatharathorn1,2, Andrea L Roberts3, Lori B Chibnik2,4
1Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.
Biological psychiatry global open science
|July 31, 2023
概括
严重的心理痛苦,标志着同时发生的创伤后应激障碍 (PTSD) 和抑郁症,与白细胞端粒长度 (LTL) 的缩短有关,这是细胞衰老标志物. 这表明,在结合创伤后果的个体中,生物衰老加速.
科学领域:
- 细胞和分子生物学 细胞和分子生物学
- 精神病学和心理学 精神病学和心理学
- 老年学和衰老研究研究.
背景情况:
- 白细胞端粒长度 (LTL) 是细胞衰老的生物标志物,与死亡率和与年龄相关的疾病有关.
- 以前的研究将创伤暴露,创伤后应激障碍 (PTSD) 和抑郁症单独与LTL联系起来.
- 创伤及其心理后果对LTL的综合影响仍未得到研究.
研究的目的:
- 在女性中调查终身创伤暴露,PTSD和抑郁症与LTL的联合关联.
- 确定心理困扰,特别是伴随性PTSD和抑郁症,是否会影响细胞衰老标志物.
主要方法:
- 从护士健康研究II中对1868名女性的一个子集的LTL分析.
- 用验证的措施评估终身创伤,创伤后应激障碍和抑郁症.
- 通过定量实时PCR和使用线性回归模型进行分析来量化LTL,并根据健康行为和医疗条件进行调整.
主要成果:
- 单独来看,创伤,PTSD和抑郁症在相互调整的模型中与LTL没有显著的关联.
- 患有严重心理困扰 (并发性PTSD和抑郁症) 的个人表现出较短的LTL,相当于7.62年的加速衰老.
- 这种联系在那些患有最多PTSD症状和并发性抑郁症的人群中最为明显,相当于增加了9.71年的衰老.
结论:
- 严重的心理困扰,特点是并发性PTSD和抑郁症,与白细胞端粒长度缩短有关.
- 这一发现表明,创伤的综合心理后果可能会在细胞水平上加速生物衰老.
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