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焦虑在看电影时塑造了杏仁体前额头动力学
Peter A Kirk1,2,3, Avram J Holmes3,4, Oliver J Robinson1,5
1Institute of Cognitive Neuroscience, University College London, London, United Kingdom.
Biological psychiatry global open science
|July 31, 2023
概括
焦虑会影响杏仁体和dorsomedial prefrontal cortex (dmPFC) 在充满悬念的电影中如何连接. 高度焦虑可能会降低在这个大脑电路中对悬疑线索的敏感性.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 精神病学是一个精神病学.
背景情况:
- 杏仁体和dorsomedial前额叶皮层 (dmPFC) 电路对于在焦虑中检测威胁至关重要.
- 了解这种电路在自然环境中的功能至关重要,但仍然不清楚.
研究的目的:
- 在自然主义的电影观看范式中调查焦虑水平与杏仁体和dmPFC之间的动态功能连接之间的关系.
- 探索焦虑性电影特征,特别是悬疑,如何调节与个人焦虑水平相关的神经电路.
主要方法:
- 利用来自剑桥衰老神经科学中心的大型,开放的功能磁共振成像 (fMRI) 数据集 (n=630).
- 采用了跨主体表示相似性分析来检查动态功能连接模式.
- 评估了焦虑,注意力偏向于恐惧的面孔,以及电影悬疑评分.
主要成果:
- 在整个电影中没有发现焦虑对动态杏仁体-dmPFC连接的整体影响.
- 一个显著的相互作用出现了:杏仁体-dmPFC电路被电影悬疑调节在低焦虑个体,但显示高焦虑个体的敏感性降低.
- 威胁相关的注意偏差与连接模式和悬念有关,这表明与焦虑机制的联系.
结论:
- 焦虑会影响杏仁体-dmPFC连接的动态,特别是在应对焦虑刺激时,如悬念.
- 这些发现表明,高度焦虑可能会改变个人处理与威胁相关的信息的方式,可能是通过改变习惯或预期.
- 需要进一步的研究来阐明这些与焦虑相关的连接差异的精确时间和机制基础.
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