ангиотензин II 1 型受体抗体介导的拒不响应治疗
David Allison1, Zahraa Hajjiri2, Luis Manon1
1Pathology, University of Illinois at Chicago, Chicago, USA.
Cureus
|July 31, 2023
概括
抗体介导的抗体排斥 (AT1R-AMR) 可能导致移植失败. 在两个案例中,标准的抗排斥疗法,包括血交换,未能从AT1R-AMR中拯救所有移植物.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 临床医学 临床医学
背景情况:
- 异种移植的排斥是造成移植失败的主要原因.
- 抗体介导的抗体排斥 (AT1R-AMR) 是一种新出现的排斥原因,通常没有可检测的HLA抗体.
- 对AT1R-AMR的治疗反应是可变的,有些病例耐治疗.
研究的目的:
- 介绍一下两例移植接受者因AT1R-AMR而经历异种移植排斥的病例.
- 评估标准抗排斥疗法的有效性,包括治疗性血交换,以控制AT1R-AMR.
- 要突出拯救受AT1R-AMR.影响的脏全移植所面临的挑战.
主要方法:
- 两名脏移植接受者的案例报告.
- 在临床表现和抗体测试的基础上诊断AT1R-AMR.
- 进行的治疗包括标准的抗排斥方案和治疗性血交换.
主要成果:
- 这两名患者都呈现出因AT1R-AMR而导致的异种移植排斥.
- 尽管进行了积极的抗排斥治疗和治疗性血交换,但这两种移植最终都被丢失了.
- 这些病例说明了AT1R-AMR的潜在治疗耐药性过程.
结论:
- AT1R-AMR对移植的生存构成重大威胁.
- 标准的抗排斥疗法,包括血交换,可能不足以在所有AT1R-AMR病例中挽救移植.
- 需要进一步的研究来确定AT1R-AMR的有效治疗策略.
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