全球发育迟缓的病因概况在印度一家三级医院:一项观察性研究
Amulya R Sharma1, Mohd Saeed Siddiqui1, Suvarna Magar1
1Department of Paediatrics, Mahatma Gandhi Mission's (MGM) Medical College and Hospital, A Constituent Unit of MGM Institute of Health Sciences, Aurangabad, IND.
Cureus
|July 31, 2023
概括
印度的全球发育迟缓 (GDD) 通常是由遗传和染色体异常等产前因素引起的. 改善围产期护理和基因检测是理解和预防GDD的关键.
科学领域:
- 儿科 儿科 儿科
- 遗传学 是一个遗传学.
- 神经学 神经学
背景情况:
- 全球发育迟缓 (GDD) 对受影响的儿童,家庭和社会构成重大挑战.
- 了解GDD的原因对于有效的管理和预防至关重要.
- 关于发展中国家GDD病因概况的数据有限.
研究的目的:
- 确定儿童全球发育迟缓 (GDD) 的病因概况.
- 调查产前,产周和产后因素对GDD的贡献.
- 评估基因测试在诊断GDD原因中的有用性.
主要方法:
- 进行了一项观察性研究,对52名3个月至5岁的儿童进行了观察,其发育系数低于70%.
- 收集的数据包括人口统计,临床特征,调查和诊断.
- 病因被分为产前,产周和产后类别.
主要成果:
- 在50%的病例中发现了产前原因,其中遗传 (32.7%) 和染色体 (7.7%) 异常最常见.
- 围产原因占34.6%,特别是缺氧缺血性脑病变 (26.7%).
- 总体病因产量达到88.4%,少数病例仍未确定.
结论:
- 产前因素,特别是遗传和染色体异常,是GDD的主要贡献者.
- 基因检测显著改善了GDD原因的识别.
- 缺氧缺血性脑病变强调了围产期护理在预防发育迟缓方面的关键作用.
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