前额叶皮质对老年人双重任务范式的血液动力反应:系统性审查和元分析
Kulvara Lapanan1,2, Phunsuk Kantha3,4, Gallayaporn Nantachai1,5
1Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Heliyon
|July 31, 2023
概括
双重任务模式增加了老年人前额叶皮质 (PFC) 中的氧化血红蛋白,表明大脑激活率更高. 这一发现可能解释了老年人群中跌倒风险的增加.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物医学工程 生物医学工程
背景情况:
- 功能近红外光谱 (fNIRS) 测量大脑血液动力学.
- 在双重任务期间前额皮层 (PFC) 血液动力学变化对于了解老年人身体活动至关重要.
研究的目的:
- 系统地审查和元分析双任务模式对老年人PFC血液动力学的影响.
主要方法:
- 搜索了PubMed,Scopus和科学网络 (直到2023年3月).
- 包括测量氧化血红蛋白 (HbO2) 和脱氧化血红蛋白 (HbR) 的研究.
- 使用I2统计数据进行异质性和子组分析,用于认知任务类型.
主要成果:
- 审查了37项研究;对25项研究 (2224名老年人) 进行了元分析.
- 抑制性控制和工作记忆任务显著增加了PFC HbO2 (分别为0.53和0.13μmol/L).
- 双重任务增加了整体PFCHbO2 (0.36μmol/L) 并降低了HbR (0.04μmol/L).
结论:
- 抑制性控制任务需要更多的认知资源,导致老年人更高的PFC激活.
- 在双重任务期间增加PFC HbO2和减少HbR可能解释了为什么老年人更容易跌倒.
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