同一天与延迟模拟成像在放置一个围直水凝间隔器后,用于前列腺放射治疗
Elisha Fredman1, Miriam Weinstock-Sabbah1, Oded Icht1
1Department of Radiation Oncology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikvah, Israel.
Frontiers in oncology
|July 31, 2023
概括
在为前列腺辐射放置水凝间隔器后,同一天的CT模拟可能会增加直肠剂量变化. 延迟模拟 (1-2周) 允许更稳定的解剖学,可能改善直肠剂量测试结果.
科学领域:
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 在前列腺放射治疗期间,周向水凝间隔器减少了直肠毒性.
- 在水凝放置后CT模拟的最佳时间尚未确定.
研究的目的:
- 根据水凝间隔器放置后CT模拟的时间,比较直肠剂量测试结果.
- 为了评估同日和延迟模拟协议之间的水凝体积和周直距离的变化.
主要方法:
- 30名患有局部前列腺腺癌的患者接受了通过直肠超声波引导的水凝间隔器放置.
- 患者被随机分配到同一天的CT模拟 (n=15) 或延迟模拟 (1-2周后) (n=15).
- 通过CT模拟和Cone-Beam-CT (CBCT) 在分数1和最后评估了水凝体积,周直径距离和直肠剂量.
主要成果:
- 同一天的模拟显示,与延迟的模拟相比,水凝体积和周直距离的减少明显更大.
- 在同一天的组中,直肠剂量参数被超过的频率更高 (5对1参数).
- 更高比例的直肠剂量参数 (10对1) 在同一天的组中显示了≥20%的相对增加.
结论:
- 在水凝间隔器放置后,同一天的CT模拟可以导致直肠剂量计的意外变化.
- 推迟模拟 (1-2周) 可能是最好的,以允许解剖稳定.
- 这些发现表明,优化模拟时间表可以改善前列腺放射治疗中的直肠剂量节约.
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