两种Inonotus hispidus菌株之间的基因组比较,这些菌株是从不同树种中生长而分离出来的
Qingchun Wang1,2, Haiying Bao1,2, Zhijun Li1,2
1Key Laboratory for Development and Utilization of Fungi Traditional Chinese Medicine Resources, Jilin Agricultural University, Changchun, Jilin, China.
Frontiers in genetics
|July 31, 2023
概括
来自Morus alba (MA) 和Fraxinus mandshurica (FM) 的Inonotus hispidus的基因组比较显示,FM的基因含量更高. 这支持FM FM.
科学领域:
- 菌类学 菌类学是指菌类学.
- 基因组学就是基因组学.
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- (Sanghuang) 是一个传统的中国医学.
- 它的遗传基础与宿主树有所不同,如Morus alba (MA) 和Fraxinus mandshurica (FM).
- 以前的研究没有比较来自不同宿主的I. hispidus遗传物质.
研究的目的:
- 来自MA和FM的I.hispidus进行比较基因组分析.
- 调查影响药物应用的遗传差异.
主要方法:
- 全基因组测序MA单核细胞 (Illumina和Pac Bio) 的测序.
- 基因组组装,组件预测和功能注释.
- 在FM和MA单核细胞之间进行比较基因组学分析,使用MA作为参考.
主要成果:
- 马氏体基因组包括24个结合体,长度为2.6 Mb N50.
- 基因注释确定了5,342个 (GO),6,564个 (KEGG),1,595个 (KOG),383个 (CAZymes) 和123个 (CYP450) 基因.
- 与MA相比,FM显示了更多的编码和注释基因.
结论:
- 这项研究为FM的药用提供了遗传基础.
- 对比基因组学突出了基于宿主树的I. hispidus遗传变异.
- 研究结果支持FM作为MA的药用替代品的潜力.
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