爪牛皮:对目前可用的全身治疗方法的最新审查
Teresa Battista1, Massimiliano Scalvenzi1, Fabrizio Martora1
1Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Clinical, cosmetic and investigational dermatology
|July 31, 2023
概括
系统性治疗对指甲牛皮 (NP) 有效,这是一个具有挑战性的疾病. 对NP的治疗选择取决于疾病的严重程度,牛皮关节炎 (PsA) 的存在,并发症和患者的偏好.
科学领域:
- 皮肤病学 皮肤病学
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 指甲牛皮 (NP) 影响了10-82%的牛皮 (PsO) 患者,这对治疗提出了重大挑战.
- 牛皮是一种常见且难以治疗的牛皮的表现.
研究的目的:
- 审查可用的全身治疗指甲牛皮的方法.
- 描述专注于指甲牛皮治疗的临床试验.
主要方法:
- 在PubMed和Embase进行了全面的文献搜索,截至2023年2月.
- 关键词包括"指甲"",牛皮"",系统疗法"和"系统治疗".
- 分析了47项原始研究和病例报告.
主要成果:
- 系统疗法推用于NP涉及>3个指甲,广泛的皮肤/关节参与,或显著的生活质量 (QoL) 影响,由于优越的长期疗效.
- 常规和生物系统性药物,包括阿西特雷丁,甲铁酸盐,环素,阿普雷米拉斯和各种生物药物 (阿达利穆马布,因弗利西马布,埃坦塞普特等). ) 在临床试验中显示出有效性.
- 广泛的系统性药物在治疗指甲牛皮方面表现出有效性.
结论:
- 多种疗法在治疗指甲牛皮方面显示出有效性和安全性.
- 治疗选择需要考虑指甲感染的严重程度,牛皮关节炎 (PsA) 状态,并发症,先前的治疗和患者的偏好.
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