肺高血压预测严重的COVID-19感染患者的死亡率更高
Ruth Minkin1, Roger Hopson1, Kumudha Ramasubbu1
1NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY, USA.
SAGE open medicine
|July 31, 2023
概括
患有肺高血压和COVID-19的患者面临着明显更高的死亡率. 这项研究强调了COVID-19患者肺高血压相关的严重结果,强调了进一步研究的必要性.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 潜在的健康状况,特别是心血管疾病,与更糟糕的COVID-19结果有关.
- 肺高血压 (PH) 是一种影响肺和心脏右侧动脉的疾病.
- PH对COVID-19预后的影响需要进一步调查.
研究的目的:
- 为了确定肺高血压患者在COVID-19感染后与没有PH患者相比,是否会出现更糟糕的结果.
- 分析COVID-19患者肺高血压和死亡率之间的关联.
主要方法:
- 对679名成年COVID-19患者的回顾性分析.
- 鉴定接受过胸前心声扫描 (TTE) 评估肺高血压的患者.
- 具有和没有PH的患者之间的健康参数和结果的统计比较.
主要成果:
- 经过TTE治疗的患者显示了更高的ICU入院率 (73.7%) 和急性呼吸困扰综合征 (ARDS) 患病率 (63.2%).
- 这些患者还经历了更长的住院时间和明显更高的死亡率 (59.7%) 与没有经历TTE的患者相比.
- 在TTE患者中,肺高血压患者的死亡率明显高 (80%) 比没有PH的患者 (43.8%).
结论:
- 肺高血压患者的COVID-19与高住院死亡率有关,即使经过对混因素进行调整.
- 潜在的机制包括右心室过载和炎症反应.
- 需要进一步的大规模研究来证实这些发现,并探索右心室功能障碍的作用.
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