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与炎症性肠道疾病相关的SNP增加了局部甲状腺蛋白的表达,从而在微型大犬中发展炎症

Yong Bin Teoh^1,2, Jing-Jing Jiang¹, Takeshi Yamasaki^1,3

¹Division of Molecular Psychoneuroimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Frontiers in veterinary science

|July 31, 2023

概括

一种特定的基因变异 (TG c.4567C>T) 增加了微型大公犬炎症性结直肠多体 (ICRP) 的风险. 这种基因变化会影响TG表达,激活可能成为治疗点的炎症途径.

科学领域:

兽医遗传学兽医遗传学
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

迷你大公犬的炎症性结直肠多 (ICRP) 是一种慢性疾病.
之前的研究已经确定了与ICRP相关的五种单核酸多态 (SNP).
该TG基因是被确定可能与ICRP相关的基因之一.

研究的目的:

为了研究TG c.4567C>T SNP和ICRP在微型大犬中的关联.
探索TG在IL-6放大器通路中的作用.
为了确定TG是否是ICRP的诊断或治疗目标.

主要方法:

微型大犬的基因定型为TG c.4567C>T SNP.
在体外实验评估TG表达及其对IL-6放大器的影响.
从受影响和未受影响的狗的结肠样本中分析TG,IL6和CCL2表达.

主要成果:

TG c.4567C>T 的T/T 风险等位基因在具有ICRP的犬中明显更频繁.
TG表达由IL-6和TNF-α上调,而TG缺乏抑制IL-6放大器.
重组TG增强了IL-6放大器激活,表明TG是一个正调节器.
在具有T/T风险等位基因的结肠组织中观察到TG,IL6和CCL2表达的增加.

结论:

TG c.4567C>T SNP 作为结肠中TG mRNA的表达定量特征位置 (eQTL).
这种SNP驱动的局部TG表达通过IL-6放大器增加了微型大犬的ICRP风险.
TG c.4567C>T是一种潜在的诊断标记,TG介导的IL-6放大器激活是ICRP的潜在治疗标.

关键词:

这是一个IL-6放大器.在SNP中,SNP是SNP.狗类犬类动物狗类犬类这是一种炎症炎症炎症炎症.炎症性结直肠多体微型的天犬微型的天犬甲状腺球蛋白甲状腺球蛋白

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