在患有败血症继发器官功能障碍的狗中,内皮激活和炎症的生物标志物
Sarah Gaudette1, Lisa Smart2,3, Andrew P Woodward1
1Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, VIC, Australia.
Frontiers in veterinary science
|July 31, 2023
概括
与健康的狗相比,患有败血症的狗表现出更高水平的内皮激活和炎症生物标志物. 这一发现增强了对犬病患者的败血症引起的器官衰竭和内皮功能障碍的理解.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 免疫学 免疫学 免疫学
- 病理生理学 病理生理学
背景情况:
- 内皮功能障碍是败血症相关器官衰竭的关键因素.
- 内皮细胞激活和炎症的生物标志物对于了解败血症进展至关重要.
研究的目的:
- 为了比较体内皮活化和炎症生物标志物的血度,在有败血症的狗和健康的狗之间.
- 为了研究内皮功能障碍在自然发生的犬类败血症中的作用.
主要方法:
- 一个多中心的观察性临床试验,涉及18只败血症狗和20只健康的狗.
- 使用ELISA进行血生物标记分析,检测血管内皮生长因子 (VEGF),氨酸 (HA),血原激活剂抑制剂-1 (PAI-1),·威尔布兰德因子 (vWF),IL-6,IL-8,IL-10,C反应蛋白和单细胞化学吸引蛋白-1.
- 使用APPLEFAST评分来评估疾病的严重程度.
主要成果:
- 与健康对照相比,败血症犬的大部分内皮和炎症生物标志物的平均血度显著更高.
- 血管内皮生长因子 (VEGF) 和氨酸 (HA) 在败血症狗中显著增加.
- 大多数败血症狗 (83%) 经历了死亡率,安乐死和住院死亡率高.
结论:
- 狗中自然发生的败血症与内皮激活和炎症的生物标志物增加有关.
- 这些发现有助于更深入地了解败血症病理生理学,特别是内皮功能障碍在器官衰竭中的作用.
- 这项研究强调了患有败血症和器官功能障碍的狗的严重预后.
相关概念视频
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
119
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
119
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
201
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
201