相关实验视频

Updated: Jul 20, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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一些具有多个立体中心的新型功能化异环氨基和胺衍生物的立体控制合成

Anas Semghouli1,2, Attila M Remete1, Loránd Kiss2

  • 1Institute of Pharmaceutical Chemistry, University of Szeged Eötvös u. 6 H-6720 Szeged Hungary.

RSC advances
|July 31, 2023
PubMed
概括

研究人员开发了一种对功能化环氨基酸乳和乳酸的立体控制合成方法. 这种新的方法利用双循环氨基酸的环重新排列元解,保持性中心配置.

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Preparation of Amides

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Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
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