具有谷氨耗尽和增强反应性氧物种生成的光热疗法,用于有效的抗菌治疗
Yuelan Wu1,2, Xiaoxue Liu2,3, Xiaoyu Zhang2,3
1Qingdao University Qingdao Shandong 266071 P. R. China hgao@sdfmu.edu.cn.
RSC advances
|July 31, 2023
概括
这项研究引入了一种无抗生素材料,聚多巴胺 (PDA) 改性金属有机框架 (PDA-FDM-23),用于对抗耐药细菌. 它使用光热疗法 (PTT) 来增强化学动力疗法 (CDT),实现100%的细菌消除.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 抗菌疗法是一种抗菌疗法.
背景情况:
- 抗生素耐药性对全球健康构成重大威胁,需要新的治疗策略.
- 目前的抗微生物疗法面临着挑战,因为抗药性细菌菌株的增加.
研究的目的:
- 开发一种无抗生素材料,用于协同抗菌治疗.
- 为了研究聚多巴胺修饰金属有机框架 (PDA-FDM-23) 的光热增强化学动力学效应.
主要方法:
- 制造多多巴胺 (PDA) 改性金属有机框架 (PDA-FDM-23).
- 评估PDA-FDM-23的过氧化酶类活性和谷氨 (GSH) 消耗.
- 对光热疗法 (PTT) 与化学动力疗法 (CDT) 结合的抗菌疗效的评估.
- 细胞毒性和血液溶解试验以确定生物相容性.
主要成果:
- PDA-FDM-23表现出高的过氧化酶类活性,消耗GSH产生Cu+.
- PTT显著增强了化学动力学治疗 (CDT) 的活性,导致反应性氧物种 (ROS) 爆炸.
- 达到100%的抗菌效率对黄金葡萄球菌和大肠杆菌.
- PDA-FDM-23表现出极好的生物相容性,细胞毒性和血液溶解低.
结论:
- 使用PDA-FDM-23的PTT增强的CDT策略为协同绝育提供了一种强大的无抗生素方法.
- 由于其催化活性,GSH消耗和光热特性,PDA-FDM-23显示出作为一种新型抗菌剂的前景.
- 这项工作提出了ROS介导协同灭菌的新策略,解决了抗生素耐药性的挑战.
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