肌基因作为老年人运动诱导认知变化的调解者:全面生活系统审查和元分析的协议
Wouter A J Vints1,2,3, Evrim Gökçe4, Antoine Langeard5
1Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Kaunas, Lithuania.
Frontiers in aging neuroscience
|July 31, 2023
概括
这篇生活评论探讨了运动诱导的肌如何影响老年人群的认知功能. 了解这些机制可以改进运动策略,以提高老年人大脑健康和表现.
科学领域:
- 神经科学和衰老研究研究
- 运动生理学 运动生理学
- 分子生物学分子生物学
背景情况:
- 全球人口老龄化正在增加,预期寿命与健康预期寿命之间的差距越来越大.
- 神经退行性疾病的患病率随着年龄的增长而上升,影响生活质量和医疗保健成本.
- 关联体育炼与老年人认知能力改善的机制尚不完全理解.
研究的目的:
- 系统地绘制和综合有关运动诱导的肌肉激素及其在认知增强中的作用的当前知识.
- 为了研究骨肌肉和认知领域释放的myokines之间的调解途径.
- 通过不断 (生活) 审查不断积累的研究,不断更新发现.
主要方法:
- 系统地收集了至少5年的随机对照研究.
- 在主要的科学数据库 (PubMed,EMBASE,PsycINFO等) 中进行全面的文献搜索. ) 的情况.
- 使用ROB 2和中介分析 (MASEM) 的元分析进行偏差风险评估.
主要成果:
- 主要分析将确定运动诱导的肌基因在多大程度上调解认知功能.
- 二次分析将评估运动特征和特定老年人群的影响.
- 审查协议已注册在PROSPERO (CRD42023416996) 公司.
结论:
- 了解运动 - 肌神 - 认知三位一体可以阐明有益于健康的器官间通信网络.
- 这些发现可能会为个性化炼处方提供信息,以优化肌肉激素诱导和认知增强.
- 这篇生活综述旨在完善运动方案,以改善各种老龄人口的认知功能.
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