自和生物转化会影响肝细胞癌中的索拉芬尼抗性

Ruiqi Zheng1, Shuang Weng2, Jianping Xu3

  • 1State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

概括

治疗前的因素如PI3K/AKT激活,生物转化和自会影响肝细胞癌 (HCC) 患者对索拉费尼布的反应. 关键分子ADH1A和STING1与索拉费尼布耐药性有关,这表明新的治疗点.

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