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Updated: Jul 20, 2025

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
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迈向先进的生物工艺优化:一种多尺度建模方法

Mariana Monteiro1, Sarah Fadda1, Cleo Kontoravdi1

  • 1Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.

Computational and structural biotechnology journal
|July 31, 2023
PubMed
概括

这项研究介绍了一种新的实时养策略,用于使用模型预测控制 (MPC) 进行中国仓鼠卵巢 (CHO) 细胞培养. 这种可适应的方法通过响应当前的工艺状态来优化蛋白质的生产,提高生物制药制造的效率.

关键词:
生物过程控制控制在CHO细胞中.数字双胞胎 数字双胞胎 数字双胞胎代谢优化优化 代谢优化过程系统 过程系统

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