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COVID-19无活化和不复制的病毒载体疫苗在表观遗传控制下诱导人体单细胞中的调控训练表型

Mateus da Silva Matias Antunes¹, Fabricia Heloisa Cavicchioli Sugiyama¹, Humberto Doriguetto Gravina¹

¹Laboratory of Immunology and Epigenetics, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.

Frontiers in cellular and infection microbiology

|July 31, 2023

概括

接种COVID-19疫苗可以训练单细胞,增强先天免疫力. 这种免疫训练有助于控制对无关病原体的炎症反应,补充了对SARS-CoV-2的适应性免疫反应.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

训练有素的免疫包括在暴露于病原体或疫苗后增强的先天免疫反应.
疫苗可以在单细胞和NK细胞中诱导类似记忆的反应.
接种SARS-CoV-2疫苗可能会在单细胞中诱导训练免疫力,并与适应性免疫力一起.

研究的目的:

调查COVID-19疫苗接种后的单细胞免疫类型,细胞因子和代谢概况.
探索由COVID-19疫苗诱导的单细胞免疫训练的表观遗传机制.
在单细胞中使用体外LPS刺激来评估训练免疫力.

主要方法:

分析了接种了无活化或病毒载体COVID-19疫苗的个体的单细胞.
用脂聚糖 (LPS) 进行了体外刺激,以模拟炎症挑战.
研究了免疫类型,细胞因子的产生,基因表达 (糖溶解,IRG1) 和组织蛋白修饰.

主要成果:

接种疫苗的单细胞显示出细胞因子的变化 (TNF-α,IL-6减少,IL-10增加).
观察到经典单细胞频率增加和CD163表达.
疫苗调节基因表达 (糖解,IRG1) 和减少炎症基因染色体可访问性,表明表观遗传学训练.

结论:

接种COVID-19疫苗可以增强适应性免疫力,调节天生的免疫力.
单细胞中的疫苗诱导的训练免疫力有助于控制有害的炎症反应.
表观遗传修饰调节受训单细胞中的调节性表型.

关键词:

在 COVID-19 疫情中,这是表观遗传学.一个单细胞单细胞.训练有素的免疫力疫苗疫苗疫苗疫苗

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