临床 Staphylococcus aureus 的抗微生物耐药性和病毒性基因概况:来自埃塞俄比亚的多中心研究
Rajiha A Ibrahim1,2,3, Nega Berhe1, Zelalem Mekuria3,4
1Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia.
Infection and drug resistance
|July 31, 2023
概括
埃塞俄比亚金黄色葡萄球菌菌株对常见的抗生素具有很高的耐药性. 潘顿-瓦伦丁白素 (PVL) 和葡萄球菌肠毒素基因普遍存在,特别是在年轻的患者中.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 黄金葡萄球菌 (Staphylococcus aureus) 是一个重要的病原体,引起各种感染.
- 毒性因素,如毒性冲击综合征毒素 (TSST-1) 和潘顿-瓦伦丁白血素 (PVL),有助于S. aureus的致病性.
- 了解埃塞俄比亚的抗菌素耐药性和病毒性基因流行率至关重要.
研究的目的:
- 为了确定埃塞俄比亚S. aureus分离物的抗菌素耐药性模式.
- 在这些隔离物中确定关键毒性基因,包括葡萄球菌肠毒素和PVL的流行率.
主要方法:
- 分析了来自埃塞俄比亚AMR监测站点的172个已确认的S. aureus分离物.
- 使用MALDI-TOF生物型和抗菌敏感性测试 (AST) 与VITEK®进行鉴定 2.
- 多重复合PCR检测mecA,mecC,pvl,spa和葡萄球菌肠毒素基因 (海,seb,sec,seh,sej).
主要成果:
- 观察到高耐药率:88.4%对青素,52.32%对三甲-硫甲醇,26.16%对四环素.
- 毒性基因的发病率:PVL (59.3%),脂质 (16.28%),TSST-1 (13.37%). 病毒性基因的发病率是:PVL (59.3%),脂质 (16.28%),TSST-1 (13.37%). 病毒性基因的发病率是:PVL (59.3%),脂质 (16.28%),TSST-1 (13.37%). 病毒性基因的发病率是:
- 在葡萄球菌肠毒素基因和对多种抗生素的耐药性之间发现了显著的关联;在15岁以下的患者中,PVL基因的患病率更高.
结论:
- 埃塞俄比亚的S. aureus分离体对口服抗生素表现出相当大的耐药性.
- 在PVL,皮脂,海和TSST-1基因的流行突显了它们在局部黄金色杆菌感染中的重要性.
- 需要进一步的研究和监测,以对抗黄金色杆菌感染和耐药性.
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