分子仿真和COVID-19:对全球生育能力的潜在影响
Custer C Deocaris1, Malona V Alinsug1
1Atomic Research Division, Philippine Nuclear Research Institute, Department of Science and Technology, Commonwealth Avenue, Diliman, Quezon City 1101 Philippines.
Molecular biology research communications
|July 31, 2023
概括
感染SARS-CoV-2可能会通过分子模仿引发自身免疫性疾病. 我们的研究确定了模仿病毒表位的生育蛋白,可能会影响全球生育率,特别是在高收入国家.
科学领域:
- 免疫学 免疫学 免疫学
- 生殖生物学 生殖生物学
- 病毒学 病毒学
背景情况:
- 自免疫性疾病显示SARS-CoV-2感染后的发病率增加.
- 分子仿真是一种将病毒感染与自身免疫性联系起来的机制.
- 生育率是一个关键的人口指标,具有潜在的全球健康影响.
研究的目的:
- 为了研究人类生育蛋白和SARS-CoV-2表位之间的潜在分子模仿.
- 评估已识别的模仿对全球生育率的影响.
- 确定影响SARS-CoV-2对生育能力潜在影响的人口因素.
主要方法:
- 在九种与生育相关的蛋白质 (AMH,BMP2,CUBN,DNER,ERCC1,KASH5,MSLN,TPO,ZP3) 的化查中,以检测与SARS-CoV-2 MHC-II表位体的分子模拟.
- 使用DR-,DQ-和DP-哈普类型进行皮层结合分析.
- 与COVID-19感染数据相关的全球生育率的系统分析.
主要成果:
- 确定了9种具有潜在分子模拟SARS-CoV-2表位体 (N,ORF1A,ORF1AB,S) 的生育蛋白.
- 41个人口覆盖率>50%的国家在疫情前的生育率低于2.1个出生/女性.
- 全球超过7.61亿例感染病例表明,这可能会对生育率产生影响,特别是在高收入经济体.
结论:
- 生育蛋白和SARS-CoV-2表位体之间的分子模拟是感染后自身免疫的可信机制.
- 鉴定到的模仿行为引发了人们对特定人群生育能力潜在负面影响的担忧.
- 需要进一步的研究来证实SARS-CoV-2对人类生育能力和自身免疫性疾病发展的直接影响.
相关概念视频
CRISPR
52.4K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
52.4K
Infertility in Males
295
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
295
Microorganisms in Medicine and Therapeutics
54
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
54
Infertility in Females
348
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
348


