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在移植到受损的脊髓后,神经圈的差异化

Svetlana Mykolaiivna Gramatiuk1,2,3, Yulia Viktorovna Ivanova1,4, Arsen Arsenievich Hudyma5

  • 1Department of Biotechnology, Institute of Bio-Stem Cell Rehabilitation of the Ukrainian Association of Biobanks, Kharkiv, Ukraine.

Journal of medicine and life
|July 31, 2023
PubMed
概括

来自不同来源的人类神经干细胞在脊髓损伤移植后显示出不同的生存率和分化为星球细胞. 受伤的脊髓环境显著影响其星球细胞表型的发展.

关键词:
有针对性的差异化.神经圈中的神经圈.脊髓损伤导致的脊髓损伤干细胞是干细胞的组成部分.

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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